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AI-Edigene? EGFR p.L747_T751delinsP Reference Standard Plus

CBP10749

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Introduction 
Format Genomic DNA
Description EGFR E746_A750del results in the deletion of five amino acids in the kinase domain of the Egfr protein from amino acids 746 to 750. E746_A750del results in increased Egfr kinase activity, activation of p44/42 MAPK and AKT in cell culture, promotes tumor growth in xenograft models, and is transforming in cell culture.
   
Technical Data 
DNA Change c.2239_2253delinsCCT
AA Change p.L747_T751delinsP
Mutation type Deletion - In frame
Zygosity Heterozygous
Allelic Frequency 50%
Transcript ENST00000275493
Cosmic ID N/A
Chr position(GRCh37) chr7:55242469-55242483
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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