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NPM1(E4)-ALK(E20) Fusion

CBP20032R

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Introduction 
Format RNA
Description NPM1-ALK fusion protein p80 is derived from the fusion of the N-terminal oligomerization domain of NPM1 (1–110 aa) and the C-terminal tyrosine kinase domain of ALK (1058–1620 aa). In these malignancies, the homo-dimerization of NPM1-ALK leads the constitutive activation of a fusion kinase in a ligand-independent manner. The persistently active tyrosine kinase NPM1-ALK triggers multiple intracellular downstream signaling pathways including AKT, ERK1/2, and STAT3, which results in proliferation and survival of ALCL cells.
   
Technical Data 
Left Gene NPM1
Left Breakpoint chr5:170818803:+ (hg19)
Transcript NM_002520.7
Right Gene ALK
Right Breakpoint chr2:29446394:- (hg19)
Transcript NM_004304.5
Cosmic ID COSF198
Buffer RNase-free H2O
   
Product Information
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purity Download for COA
RNA electrophoresis Download for COA
Sanger sequencing
Storage -90~ -70℃
Expiry 12 months from the date of manufacture

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藥靶模型聯(lián)系方式: 華東銷售經(jīng)理(上海):18240630236 華東銷售經(jīng)理(上海、江蘇、安徽):15715191010 華中&華西銷售經(jīng)理:18071545918 華中&西南銷售經(jīng)理:13871580511 華北銷售經(jīng)理:18628311252 全國銷售經(jīng)理:13816461235
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