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首頁(yè) /診斷試劑 /腫瘤標(biāo)準(zhǔn)品 /Mutation /AI-Edigene? BRAF p.V600D Reference Standard Plus

AI-Edigene? BRAF p.V600D Reference Standard Plus

CBP10423

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產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
Introduction 
Format Genomic DNA
Description

BRAF is a member of the RAF family that is activated by members of the Ras family upon growth factor-induced stimulation. Active Ras can induce heterodimerization of cRaf and BRAF and this may explain the observed cooperativity of cRaf and BRaf in cells responding to growth factor signals. Activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations result in a valine to glutamic acid change at residue 600 within the activation segment of B-RAF .

   
Technical Data 
DNA Change c.1799_1800TG>AT
AA Change p.V600D
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000288602
Cosmic ID COSM477
Chr position(GRCh37) chr7:140453135_140453136
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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